There is overwhelming evidence that refugees are at an increased risk for developing mental health disorders. Simultaneously, there is a mental health prevention and treatment gap, not only in low and middle-income countries but also in high-income settings, such as Switzerland. Innovative solutions and strategies have been developed in the Cantons of Vaud and Zurich to address the needs of children and adolescent refugees. In the Canton of Vaud, a special training program for professionals who work closely with unaccompanied minors and a transcultural unit were established to facilitate access to mental health services. To meet the needs of Ukrainian refugees in the Canton of Zurich, a newly developed EASE (Early Adolescent Skills for Emotions) program, a scalable psychological intervention by the WHO, designed for adolescents experiencing distress has been implemented. With the number of forcibly displaced children and adolescents expected to grow exponentially in the coming years, prevention efforts in mental health will be critical.