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Titre de l’article Childhood adversity and DNA methylation of Brain-derived Neurotrophic Factor (BDNF) in young adults with previous youth residential care placement
Code d’article P01
Auteurs
  1. Nora Bürge Conférencier
  2. Maria Meier Universität Konstanz
  3. Laura Gurri Psychiatric University Hospitals, Basel, Switzerland
  4. Katharina Beck University Psychiatric Clinics Basel
  5. Delfine d'Huart Department of Youth Forensic, Psychiatric University Hospitals Basel, Basel, Switzerland
  6. Christina Stadler Universitäre Psychiatrische Kliniken Basel UPK
  7. Marc Schmid Child and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel
  8. Cyril Boonmann Leiden University Medical Center (LUMC) Curium
  9. David Bürgin Jacobs Center for Productive Youth Development, Universität Zürich, Zürich, Schweiz
  10. Eva Unternaehrer UPK Basel
Forme de présentation Poster
Domaines thématiques
  • T01 - Neurogenetics & Neurodevelopment
Résumé (Abstract) Background. Childhood Adversity (CA) can have a long-term negative impact on neurodevelopment and mental wellbeing in later life. An underlying mechanism might be epigenetic processes, such as altered DNA methylation (DNAm). One gene that might play a role is the brain-derived neurotrophic factor gene (BDNF), playing a crucial role in neuronal development and psychiatric disorders. The aim of this study is to investigate the association between CA and DNAm of the BDNF gene.
Method. In this cross-sectional study, N=117 young adults (mean age= 26.31 years; 32.5%= female) with a history of residential youth care completed the Childhood Trauma Questionnaire (CTQ) and provided blood samples for analysis of serum BDNF concentration and DNAm using the Illumina Infinium MethylationEPIC BeadChip Microarray. To investigate the association of CA and 49 CpGs clustered into 4 groups of functionally relevant gene regions of the BDNF gene, multilevel regression models were calculated, following a preregistered analyses plan (https://osf.io/74wjx).
Results. CA was not associated with DNAm in all four functionally relevant gene regions of BDNF. In addition, DNAm was not significantly associated with serum BDNF concentration. Only the covariate age was significantly associated with DNAm on BDNF of two out of four functionally relevant gene region clusters.
Conclusion. Findings of our study show no direct association between CA and DNAm on BDNF in a sample of young adults with previous youth residential care placements. However, the findings suggest an association between age and BDNF DNAm on two out of four functionally relevant gene region clusters, which included single CpGs that were found to be associated with age in previous studies. More research is needed to investigate the interplay between CA and its epigenetic influence on BDNF gene expression and the association with age.

Keywords: childhood adversity (CA), DNA methylation (DNAm), cytosine-phosphate-guanine (CpG), epigenetics, brain-derived neurotrophic factor (BDNF), high-risk sample