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Contribution title Investigation of Extrastriatal Dopamine D1 and D2 Receptor Densities in 22q11.2 Deletion Syndrome: A PET Study Using 11CSCH23390 and 11CFLB457
Contribution code D2.101
Authors
  1. Yasuharu Yamamoto National Institutes for Quantum Science and Technology Presenter
  2. Keisuke Takahata National Institutes for Quantum Science and Technology
  3. Yutaka Kato Tsutsuji Mental Hospital
  4. Hajime Tabuchi Tsutsuji Mental Hospital
  5. Yuichi Takei Gunma University Graduate School of Medicine Department of Psychiatry and Neuroscience
  6. Masakazu Sunaga Gunma University
  7. Bun Yamagata Keio University School of Medicine
  8. Jinichi Hirano Keio University School of Medicine
  9. Sho Moriguchi National Institutes for Quantum Science and Technology
  10. Makoto Higuchi National Institutes for Quantum Science and Technology
Form of presentation Poster
Topic
  • T24 - Neuroimaging
Abstract Aims:
To investigate striatal extrastriatal dopamine D1 and D2 receptor densities in patients with 22q11.2 deletion syndrome (22q11DS) using 11CSCH23390 and 11CFLB457 PET imaging.

Methods:
Five 22q11DS patients and ten healthy controls underwent PET scans with 11CSCH23390 and 11CFLB457 to measure D1 and D2 receptor densities, respectively. Regions of interest included the frontal, temporal, parietal, and occipital lobes, and thalamus. Binding potential was calculated using the simplified reference tissue model with the cerebellum as the reference region. Clinical assessments included the Structured Interview for Prodromal Syndromes (SIPS) and Wechsler Adult Intelligence Scale (WAIS-III).

Results and Conclusions:
22q11DS patients showed significantly increased D1 receptor density in the temporal lobe compared to healthy controls, after controlling for age and sex (p = 0.019). No significant group differences were observed in D2 receptor density or in other brain regions for D1 receptors. Both groups exhibited age-related decreases in D1 and D2 receptor densities across all regions. This study provides the first evidence of altered extrastriatal dopamine receptor density in 22q11DS, specifically increased D1 receptor density in the temporal lobe. These findings suggest potential dysregulation of the dopaminergic system in 22q11DS, which may contribute to the increased risk of psychiatric symptoms in this population. Further research with larger sample sizes is needed to explore the relationship between receptor density and clinical symptoms in 22q11DS.