21st international Congress of the ESCAP 2025
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Contribution title Long-term Trajectory of Cognitive Functions in Early-Onset Psychotic Disorder: A Ten-Year Follow-Up Study
Contribution code D2.115
Authors
  1. Elena De la Serna CIBERSAM, H.Clínic. Presenter
  2. Immaculada Baeza Hospital Clinic of Barcelona
  3. Daniel Ilzarbe H.Clínic, CIBERSAM
  4. Gisela Sugranyes Institut Clinic de Neurociències, Hospital Clínic i Provincial
  5. Patricia Camprodon-Boadas Institut Clinic de Neurociències, Hospital Clínic Universitari, Barcelona, 08036, Spain
  6. Adriana Fortea
  7. Olga Puig H.Clínic, CIBERSAM
  8. Maria Ortuño
  9. Irene Martinez
  10. Josefina Castro-Fornieles University of Barcelona
Form of presentation Poster
Topic
  • T32 - Psychosis
Abstract Background: Psychotic disorders are severe mental disorders where a younger age of onset is associated with worse outcomes. Long-term studies analyzing the trajectory of cognitive functions are scarce and controversial. This study analyzes the ten-year follow-up evolution of cognitive functions in a sample of patients with an Early Onset Psychotic disorder (EOP).
Methods: 24 patients with an EOP and 25 healthy controls (HC) were included. Cognitive assessment consisted of a neuropsychological battery at baseline and at ten-year follow-up (intelligence quotient, working memory, verbal memory, and executive functions). Multilevel mixed-effect logistic regression models (categorical variables) or multilevel mixed-effect linear regression models (continuous variables) were used to study changes in cognition over time.
Results: No significant differences were observed between EOP and HC in age and sex. Nevertheless, EOP patients had lower socio-economic status both at baseline and at ten-year follow-up compared to HC. Regarding cognitive functions, significant differences were observed between EOP and HC in all cognitive domains, with EOP patients showing lower scores than HC in all variables. Nevertheless, no group-by-time interaction was significant in any variable.
Conclusions: Cognitive difficulties are global and observable from the first episode of the disorder in patients with EOP. These difficulties remain constant over time in this sample. Longer follow-up studies will be needed to explore the evolution of cognitive performance in elderly patients with EOP. This study was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III(PI20/00654), co-financed by the European Union “A way of making Europe”