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Contribution title Effects of parental characteristics on the risk of psychopathology in offspring. A four-year follow-up study
Contribution code D2.116
Authors
  1. Elena De la Serna CIBERSAM, H.Clínic. Presenter
  2. Dolores Moreno
  3. Gisela Sugranyes Institut Clinic de Neurociències, Hospital Clínic i Provincial
  4. Patricia Camprodon-Boadas Institut Clinic de Neurociències, Hospital Clínic Universitari, Barcelona, 08036, Spain
  5. Daniel Ilzarbe H.Clínic, CIBERSAM
  6. Immaculada Baeza Hospital Clinic of Barcelona
  7. Sara Parrilla
  8. Covadonga Martinez
  9. Carmen Moreno Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, CIBERSAM, IiSGM, School of Medicine, Universidad Complutense de Madrid
  10. Josefina Castro-Fornieles University of Barcelona
Form of presentation Poster
Topic
  • T32 - Psychosis
Abstract Aims: To assess psychopathology and prodromal psychotic/bipolar symptoms in offspring of patients diagnosed with schizophrenia (SZoff) or bipolar disorder (BDoff). To study the effects of parental characteristics on offspring’s risk of developing psychopathology.
Methods: This is part of the BASYS study that included 90 BDoff, 41 SZoff, and 10 controls (CCoff) aged 6 to 17 years at baseline. Parents’ and offspring’s psychiatric diagnoses, socio-economic status (SES), global functioning, parents’ ages at childbirth, and offspring prodromal symptoms were assessed. The risk of psychiatric disorders and prodromal psychotic/bipolar symptoms in the offspring was analyzed using Kaplan-Meier. The association of some parents’ variables and risk of psychopathology and prodromal psychotic/bipolar symptoms was studied using a Cox regression analysis.
Results: SZoff and BDoff had a higher risk of psychopathology than CCoff at four-year follow-up. SZoff showed a higher risk for ADHD, disruptive disorders, and prodromal psychotic symptoms, whereas BDoff displayed a heightened risk for mood disorders, ADHD and prodromal bipolar symptoms when compared to CCoff. Higher parental psychosocial functioning and SES were associated with lower prevalence of psychopathology.
Conclusions: Both SZoff and BDoff samples present higher risk of developing psychopathology but the pattern of this psychopathology seems to be group specific. Longer follow-up studies are needed to assess the capacity of psychopathological disorder and prodromal symptoms to predict progression to full-fledged disorders. This study was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III(PI21/00519), co-financed by the European Union “A way of making Europe” and Fundació Marató de TV3.