21st international Congress of the ESCAP 2025
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Contribution title Disease and biochemical predictors of Bone Mineral Density in adolescents with Anorexia Nervosa: preliminary results
Contribution code D2.085
Authors
  1. Anna Riva Fondazione IRCCS San Gerardo dei Tintori, Monza, and University of Milano-Bicocca, Milan Presenter
  2. Gabriele Arienti Fondazione IRCCS San Gerardo dei Tintori
  3. Simone Ravizza University of Brescia
  4. sofia elena sforza
  5. alessandro cattoni
  6. paolo passoni
  7. Renata Nacinovich Fondazione IRCCS San Gerardo dei Tintori, Monza, and University of Milano-Bicocca, Milan
Form of presentation Poster
Topic
  • T18 - Eating disorders
Abstract Aims
Individuals with Anorexia Nervosa (AN) suffer organic comorbidities due to malnutrition. Among these, prolonged amenorrhea is common, with consequences on bone mineral density (BMD) and also increased risk of osteopenia and osteoporosis. Aims of the present research are to evaluate the correlations, in a sample of female adolescents with AN, between bone data and clinical and biochemical data and to determine potential predictors of reduced BMD.

Methods
A total of 41 female adolescents aged between 14 and 18 with a diagnosis of AN were recruited.
Spearman correlation analyses between BMD, clinical and biochemical data were carried out. The most statistically and clinically significant correlations were used in multiple linear regression analyses to determine potential predictors of BMD.

Results and conculsions
Statistically significant correlations emerged between premorbid SDS Body Mass Index (BMI), SDS BMI at diagnosis, alkaline phosphatase values, and total, lumbar and femoral BMD Z-scores and BMAD Z-scores. Multiple linear regression models highlighted statistically significant correlations between alkaline phosphatase and bone data.
The preliminary results of the study thus confirmed that premorbid BMI and BMI at diagnosis correctly predict BMD, confirming the relevance of weight recovery in adolescents with AN. Alkaline phosphatase, if confirmed as a predictor of osteopenia in these patients, could be properly used as an early marker for osteopenia risk.