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Contribution title NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) encoding the glucocorticoid receptor, gene expression levels in mononuclear cells and risk for PTSD
Contribution code D3.138
Authors
  1. Yossi Martin bThe Herman-Danna Department of Child and Adolescent Psychiatry, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel Presenter
  2. Amit Shalev Hadassah Medical Organization and Faculty of Medicine Hebrew University of Jerusalem
  3. Tanya Goltser-Dubner
  4. Fortu Benarroch Hadassah Medical Center and Faculty of Medicine Hebrew University of Jerusalem
  5. Ronen Segman Molecular Psychiatry Laboratory, Department of Psychiatry, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem
Form of presentation Poster
Topic
  • T43 - Trauma
Abstract Background: Posttraumatic Stress Disorder (PTSD) is a common reason for distress, reduced functioning and an increase in physical morbidity and mortality. Altered cortisol reactivity pro inflammatory state may contribute to the increased physical morbidity. Exposure to trauma and the development of PTSD may cause gene regulatory changes in mononuclear cells and may be used as a marker in the prediction of both the expression and the developmental course of the disease.
Aims: Identify the contribution of the putative changes in the expression levels of the NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) encoding the glucocorticoid receptor in mononuclear cells to the development of PTSD among survivors of acute traumatic events.
Methods: Comparison of mononuclear cell NR3C1gene expression levels among 200 trauma exposed adolescents and adults between those who did or did not develop PTSD after an acute traumatic event, using the Caps-5 interview and additional questionnaires validated by the literature.
Preliminary Results: So far, a partial sample has been recruited. I will complete the sample size to 200 subjects, incorporating psychiatric interviews, scales, blood collection, and the processing of mononuclear cells. Additionally, I will assist in establishing the laboratory methods for analyzing NR3C1 gene expression under supervision and contribute to the analysis and reporting of the results.
Study Relevance: Identifying a unique signal of altered blood NR3C1mononuclear cell expression related to the development of PTSD will broaden our perspective on the transcriptional reprogramming of the endocrine – immune interactions regulated by NR3C1 and their potential involvement in the development of PTSD and may help discover a biomarker to predict the risk for developing PTSD.