While there has been a steady growing interest on the clinical and public health implications of bipolar disorder affecting children and adolescents, research in Europe is limited, and most knowledge to date comes from US studies making it difficult to extrapolate findings to European clinical settings. To cover this gap in research, this symposium will report on recent data from European studies on early-onset bipolar disorder and bipolar disorder offspring. Neuroimaging and inflammatory processes in bipolar youth and risk factors for psychopathology in bipolar offspring will be reported. A review on current status of treatment interventions for bipolar children and adolescents will also be included.