The symposium will present selected findings from the multi-center study UBICA (Understanding and breaking the intergenerational cycle of abuse). First, Dittrich et al. will talk about transgenerational effects of maternal childhood adversity (CA) and/or a history of depression on the quality of interaction with their five to twelve years old children and on children’s well-being. Based on data of the same sample, Möhler et al. will present findings on transgenerational effects of maternal CA and/or depression on the inhibitory functioning of children. Subsequently, Reichl et al. will discuss the moderating role of polymorphisms from the oxytocin receptor gene on relations between maternal CA and parenting behavior. Consequently, Dahmen et al. will compare a group of adolescent and adult mothers and their three to six months old infants regarding psychosocial risk factors, the quality of mother-child interaction and maternal and children’s well-being. Finally, Fuchs et al. will present findings about longitudinal effects of maternal CA on the adrenocortical attunement in mothers and their three years old toddlers.