Authors:
PhD Nevena Dimitrova | Switzerland
Helene Turpin
Francois Ansermet
Dr Ayala Borghini
Mathilde Morisod Harari
Carole Muller-Nix
PD Dr Sébastien Urben
Objectives: Very preterm (VP) birth refers to an early stressful event putting children at heightened risk for behavioral and emotional difficulties. However, it remains unknown whether early emotional difficulties persist later in childhood and, importantly, whether the severity of the perinatal stress moderates this link.
Methods: 36 VP children and 23 full-term born (FT) children participated in an 11 year-long study. Perinatal stress was assessed at birth with the Perinatal Risk Inventory (PERI groups: low PERI: 100% of FT vs. 44% of VP children; high PERI: 56% of VP children). Early emotional problems were reported by mothers at 18 months in the behavioral and emotional disorders subscale (BE) of the Symptom Checklist. Later emotional problems at 11 years of age were reported by mothers through the internalizing problems (IP) subscale of the Child Behavior Checklist.
Results: First, examining whether the severity of perinatal stress affects IP, a t-test indicated significant differences between the low (M=51.92, SD=8.43) and high (M=59.60, SD=11.64) PERI groups (t(55)=-2.865, p=.006). Second, we correlated BE at 18 months with IP at 11 years and found a significant link in the high PERI group (r=.618, p=.004) but not in the low PERI group (r=.015, p=.933). Last, controlling for socio-economic status and intelligence quotient, we performed a regression analysis predicting child IP at 11 years by group (VP vs. FT), PERI groups (high vs. low), and BE at 18 months (main effects), as well as the interaction term of BE at 18 months with either group and PERI groups. This regression model significantly explained 36% of the variance in child IP at 11 years, F(7,52)=3.68, p=.003, R2change=.140. Specifically, the interaction between BE at 18 months and PERI groups refers to a significant predictor of later IP. Further analyses revealed that BE at 18 months marginally predicted children’s IP at 11 years only in the high PERI group (β=.418, p=.063), but not in the low PERI group (β =-.048, p=.801).
Conclusion: Prematurity affects children’s emotional abilities. Importantly, the link between emotional problems in early and later childhood is moderated by the severity of the perinatal stress. In particular, children who are born with more complications, experience more stress in the perinatal period, and are more likely to sustain their early emotional difficulties later in childhood.