Autism spectrum disorders are a heterogeneous group of pervasive neurodevelopmental disorders that affects up to 1 in 68 children. ASD manifest with deficits in social communication, and the presence of repetitive behaviors or restricted interests, appearing before the age 3. To date, behavioral interventions have proven effective to get the most optimal long-term benefits, either with early intensive intervention for preschoolers or cognitive remediation for school-age children and adolescents with ASD. However, we still don’t understand well the neurodevelopmental mechanisms by which these interventions work. In this symposium, researchers will present different ways of measuring how much and by which mechanisms behavioral intervention might help affected children.