Detailed contribution information
| Contribution title | 2491 - Self-rated impulsivity associated with prefrontal hemodynamic responses in young adults with major depressive disorder |
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| Contribution code | PS02-53 (P) |
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| Form of presentation | Poster |
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| Abstract |
Objectives: Young adults often exhibit greater impulsivity, resulting in increased accidents because of drug or alcohol use and an increased mortality risk. Previous studies using near-infrared spectroscopy (NIRS) have reported that compared with control subjects, adult patients with major depressive disorder (MDD) showed significantly reduced hemodynamic responses in frontotemporal regions during executive function tasks. However, it is unclear whether these patterns on hemodynamic responses are observed in young adults with MDD and whether these differences are associated with impulsivity. We assessed the association between frontotemporal function and impulsivity in young adults with MDD. Methods: Twenty-four young adults with MDD (age range, 19–30 years) and 26 healthy control (HC) subjects matched by age, sex ratio, and estimated IQ participated in the study. Regional hemodynamic responses during a verbal fluency task were monitored using NIRS. We assessed 50 participants using the Barratt Impulsiveness Scale, version 11 (BIS-11). Multiple regression analysis was employed to examine the factors associated with hemodynamic responses of young adults with MDD. Results: No significant difference in the impulsivity level between young adults with MDD and HC subjects were observed. Young adults with MDD had significantly reduced activation compared with HC subjects in the frontotemporal regions, including the bilateral dorsolateral prefrontal, orbitofrontal, frontotemporal, and bilateral temporal regions. In addition, the reduced response of young adults with MDD in the orbitofrontal region was negatively correlated with the impulsivity level, whereas no significant correlation was observed with respect to this aspect in HC subjects. Factors associated with the hemodynamic response of the orbitofrontal region in young adults with MDD were impulsivity (β = −0.57, p = 0.005) and the use of antidepressants (β = 0.43, p = 0.013). Conclusions: Young adults with MDD had functional abnormalities in frontotemporal regions, especially in the orbitofrontal region that is associated with impulsivity. NIRS might be a biological marker for impulsivity in young adults with MDD. |