Detailed contribution information
| Contribution title | 2917 - TRICHOTILLOMANIA, PANDAS AND MATERNAL IMMUNE MEDIATED CONDITIONS: ADOLESCENT CASE SERIES |
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| Contribution code | PS01-72 (P) |
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| Form of presentation | Poster |
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| Abstract |
OBJECTIVES: Trichotillomania (TTM) is an impulse control disorder characterized by pulling out one’s own body hair. Psychiatric comorbidity may include Attention Deficit and Hyperactivity Disorder (ADHD), Obsessive Compulsive Disorder (OCD) and depression. Trichotillomania has been classified as Obsessive Compulsive Spectrum Disorders according to Diagnostic and Statistical Manual of Mental Disorders, DSM V. Maternal immunity may affect developing brain via cytokines and therefore the offspring may appear susceptibilities to immune mediated neurodevelopmental disorders such as PANDAS, OCD and Tourette. Especially, it is assumed that an association between streptococcal infection and early onset hair pulling. However there is no study investigating an association between autoimmunity and TTM in paediatric clinical samples. We aimed to investigate possible association between maternal immune mediated conditions and clinical characteristics of twelve TTM cases who admitted Child Adolescent Psychiatry Department over one year period. METHODS: Cases were reviewed for clinical characteristics by gender, comorbidity, maternal immune mediated conditions and PANDAS. All patients were evaluated by Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version-Turkish Version (K-SADS-PL-T) RESULTS: The mean of age was 13,3±3,3; Eight cases were female ; four cases were male. All patients had at least one comorbid diagnosis. Two patients had ADHD and Oppositional Defiant Disorder (ODD); two patients had ADHD, OCD and ODD; two patients had Tourette, ADHD and ODD; one patient had Tourette and ADHD; one patient had OCD; one patient had OCD and social phobia; two patients had ADHD; one patient had Anorexia Nervosa. Four patients had PANDAS, one patient had Type 1 Diabetes Mellitus; one patient had epilepsy. Maternal immune conditions were seen in four cases: one had Familial Mediterrean Fever; one had lupus and Hashimoto thyroiditis; one had Hashimoto thyroiditis and sister with celiac disease; one had Acute Rheumatic Fever. Five cases had maternal allergic asthma. Only two patients had no maternal immune disease history. CONCLUSIONS: We concluded that PANDAS, ADHD and maternal immune mediated conditions were very common in these twelve cases. This report suggested that comorbidities, maternal-offspring immune conditions might promote to understand endophenotypical aspects of TTM in the future. |