Detailed contribution information
| Contribution title | 3263 - COGNITIVE IMPAIRMENTS IN CHILDREN AND ADOLESCENT WITH PERINATAL HIV INFECTION IN POLAND |
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| Contribution code | PS03-28 (P) |
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| Form of presentation | Poster |
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| Abstract |
OBJECTIVES: The aims of the study were: (1) to evaluate the prevalence of cognitive impairments; (2) to determine the relationships between the occurrence of cognitive impairments and their clinical and sociodemographic correlates. METHODS: 56 children with perinatal HIV infection at the age of 6-18 years were qualified to the experimental group (PHIV+). Two groups, matched for age and sex, were recruited as reference groups: (1) group PHEU included 24 healthy children perinatally HIV-exposed but uninfected; (2) group HIV-nA consisted of 43 healthy children of uninfected parents. CANTAB Research Suit was used to assess cognitive functions. The five CANTAB tests were used: Motor Screening Task (MOT), Reaction Time (RTI), Stocking of Cambridge (SOC), Intra/Extra Dimensional Shift (IED), Spatial Working Memory (SWM). RESULTS: Cognitive impairments were observed in all tests in PHIV+ group. In comparison with HIV-nA group PHIV+ group scored worse in movement execution tests (Mean simple/five-choice movement time p=0,007/p=0,004), in attention switch, cognitive flexibility, feedback (Pre-ED errors p=0,044) and working memory (Between errors p=0,009). In comparison with PHEU group PHIV+ group performed significantly worse in longer planning time during test execution (Mean initial thinking time 4 moves/5 moves p=0,032/p=0,009). The analysis of results for the group of 12-18 years of age revealed the deterioration of cognitive functions in all tests in PHIV+ children in comparison with HIV-nA group. Children with PHIV+ who started treatment before 3 months of age had worse results in the use of feedback, switching attention and cognitive flexibility. Children with PHIV+ who started treatment after 12 months of age had better results in planning, the use of feedback and cognitive flexibility. Higher logarithm of viral load at the start of the ARV treatment was associated in slower processing, worse planning, use of feedback and cognitive flexibility. CONCLUSIONS: The cognitive functioning of adolescent PHIV+ (aged 12-18 years) is worse compared to HIV-nA group, with progressing deterioration of executive functioning associated with longer duration of HIV neuroinfection and treatment. More serious course of HIV infection and its severity before treatment is associated with the severity of deficits of executive functions. |