Detailed contribution information
| Contribution title | 3406 - Auditory change detection in children and adolescents with increased risk for development of schizophrenia spectrum disorder: a high-density EEG study in 22q11.2 Deletion Syndrome |
|---|---|
| Contribution code | PS03-76 (P) |
| Authors | |
| Form of presentation | Poster |
| Topic |
|
| Abstract |
OBJECTIVE: Di George Syndrome, also known as velo-cardio-facial or 22q11.2 Deletion syndrome has been associated with increased risk (24%) for the development of schizophrenia spectrum disorder during adolescence (Schneider et al., 2014). In this cross-sectional study, we examined the development of auditory sensory processing in 22q11.2 deletion syndrome (22q11.2 DS) using the auditory mismatch negativity response, a well-known change detection component that has been reported to characterize neuropathological alterations in the auditory cortex in schizophrenia and, also in individuals at risk for development of schizophrenia (Näätänen et al., 2016). METHODS: Auditory evoked potentials were measured in 16 children (8-13 years; 8 females) and 16 adolescents (14-18 years; 6 females) with 22q11.2 deletion syndrome, and in 16 healthy children (8-13 years; 7 females) and 18 healthy adolescents (14-18 years; 8 females), in an oddball paradigm with pure tone stimuli using high-density EEG. The stimuli (1000Hz - as standard and 1200Hz -as deviant) were presented binaurally in one block of 600 tones. The mismatch negativity response (MMN) exhibited by 22q11.2 DS participants was analysed in comparison with the one exhibited by typically developing participants with a focus on the age effect. RESULTS: In children, no marked differences in the mismatch negativity response were seen when comparing children with 22q11.2 DS against healthy children. However, a difference emerged in adolescence, where we found decreased amplitudes during the mismatch response on central electrodes, corresponding to reduced activations in left superior temporal gyrus in adolescents with 22q11.2 DS compared to healthy adolescents. In the between group comparison, amplitude differences in mismatch negativity were found in adolescents with 22q11.2 DS, who exhibit significantly reduced amplitudes on fronto-central channels when compared to children with 22q11.2 DS while no such differences were observed when comparing healthy children with healthy adolescents. CONCLUSIONS: These findings suggest that 22q11.2 DS participants might follow different developmental trajectories compared to healthy participants and clearly demonstrate that a prominent, developmentally disparate MMN response can be observed during adolescence that could co-occur with an increased risk for schizophrenia spectrum disorders. |