Detaillierte Beitrags-Information
| Beitragstitel | The Impact of Second-Generation Antipsychotic Medication Side-Effects on Functioning from a Schizophrenia Patient Perspective: a Cross-Sectional, Observational, Patient Centered, Web Survey Study |
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| Beitragscode | P11 |
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| Präsentationsform | Poster |
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| Abstract |
Background: The objective of the study was to understand how specific side effects (SEs) of second-generation antipsychotics (SGAs) impact daily functioning, emotional well-being, and overall quality of life of patients with schizophrenia. Methods: This was a cross-sectional, patient-reported web survey, conducted in the US including socio-demographics, Quality of Life (Q-LES-Q-SF), Glasgow Antipsychotic Side-Effect Scale (GASS), and questions on impact of SEs on functioning and emotions. Patients with schizophrenia (≥18 years), taking an SGA, and with at least one SE were included. Results: The 180 participants had a mean age of 35 years, and 58.3% were female. The lowest Q-LES-Q-SF scores were satisfaction with one’s ‘economic status’ (M=2.61), followed by ‘sexual drive’ (2.72), ‘work’ (2.75), ‘mood’ (2.88), and ‘social relationships’ (2.94). Feeling ‘drugged or like a zombie‘, ‘sleepy during the day‘, having ‘difficulties sleeping‘, feeling ‘restless‘, and gaining weight were self-reported as having an impact on their functioning by 80.6%, 63.7%, 63.3%, 62.4%, and 63.1% of participants respectively. These SEs had at least a moderate to severe impact (defined by a VAS score ≥ 50) on all aspect of functioning (physical, psychological, social, and vocational). Discussion: Findings suggest that patients taking SGAs have many SEs including activating and sedating SEs and weight gain. These SEs have negative impact on functioning and quality of life. |