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Beitragstitel The Impact of Second-Generation Antipsychotic Medication Side-Effects on Functioning from a Schizophrenia Patient Perspective: a Cross-Sectional, Observational, Patient Centered, Web Survey Study
Beitragscode P11
  1. Stine Rasmussen Meehan Lundbeck Vortragender
  2. Catherine Weiss Otsuka Pharmaceutical Development and Commercialization, Inc.
  3. William Lenderking
  4. Owen Cooper
  5. Huda Shalhoub
  6. Leah Kleinmann
  7. Mallik Greene
  8. Rajniv Tandon
  9. Randall Bender
Präsentationsform Poster
  • 07 - Pharmakotherapie
Abstract Background: The objective of the study was to understand how specific side effects (SEs) of second-generation antipsychotics (SGAs) impact daily functioning, emotional well-being, and overall quality of life of patients with schizophrenia.

Methods: This was a cross-sectional, patient-reported web survey, conducted in the US including socio-demographics, Quality of Life (Q-LES-Q-SF), Glasgow Antipsychotic Side-Effect Scale (GASS), and questions on impact of SEs on functioning and emotions. Patients with schizophrenia (≥18 years), taking an SGA, and with at least one SE were included.

Results: The 180 participants had a mean age of 35 years, and 58.3% were female. The lowest Q-LES-Q-SF scores were satisfaction with one’s ‘economic status’ (M=2.61), followed by ‘sexual drive’ (2.72), ‘work’ (2.75), ‘mood’ (2.88), and ‘social relationships’ (2.94). Feeling ‘drugged or like a zombie‘, ‘sleepy during the day‘, having ‘difficulties sleeping‘, feeling ‘restless‘, and gaining weight were self-reported as having an impact on their functioning by 80.6%, 63.7%, 63.3%, 62.4%, and 63.1% of participants respectively. These SEs had at least a moderate to severe impact (defined by a VAS score ≥ 50) on all aspect of functioning (physical, psychological, social, and vocational).

Discussion: Findings suggest that patients taking SGAs have many SEs including activating and sedating SEs and weight gain. These SEs have negative impact on functioning and quality of life.