| Auteurs |
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Christian Mikutta
Privatklinik Meiringen
Conférencier
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Bernd Feige
Faculty of Medicine, University of Freiburg, Germany
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Jonathan G. Maier
Universitäre Psychiatrische Dienste (UPD) Bern
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Elisabeth Hertenstein
HUG - Geneva University Hospitals
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Dieter Riemann
Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
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Christoph Nissen
Hôpitaux Universitaires Genève HUG
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Résumé (Abstract)
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Initially independent lines of research suggest that sleep-specific brain activity patterns, observed as electroencephalographic (EEG) slow oscillatory and sleep spindle activity, promote memory consolidation and underlying synaptic refinements. Here, we further tested the emerging concept that particularly the coordinated interplay of slow oscillations and spindle activity (phase-amplitude coupling) support memory consolidation. To address this question, we associated indices of the interplay between slow oscillatory (0.16–1.25 Hz) and spindle activity (12–16 Hz) during NREM sleep (strength [modulation index] and phase degree of coupling) in 20 healthy adults with parameters of overnight declarative (word-list task) and procedural (mirror-tracing task) memory consolidation. The pattern of results supports the notion that the coordinated interplay between oscillations facilitates memory consolidation. Specifically, the overall strength of coupling (modulation index) correlated with procedural memory consolidation (r=0.42, p=0.04), whereas, particularly, the coincidence of the spindle amplitude maximum with the up-state of the slow oscillation was significantly associated with declarative memory consolidation (r=0.65, p=0.013). Future studies are needed to test for potential causal effects of the neural mechanisms underlying the observed oscillation patterns and to elucidate ways of modulating these processes, for instance through non-invasive brain stimulation techniques.
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