Detaillierte Beitrags-Information
| Beitragstitel | Effect of Prednisolone for prevention of muscle degeneration after infraspinatus tendon release in sheep |
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| Beitragscode | P013 |
| Autoren | |
| Präsentationsform | Poster |
| Themengebiete |
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| Abstract |
Introduction: Fatty infiltration is one of the main factors which determine irreparability of rotator cuff tears. Recent observations would be compatible with an inflammatory mechanism initiated by tendon release which leads to active destructing and degeneration of the muscle cells. It was the aim of this study to explore if the suggested inflammatory muscle degeneration and fatty infiltration can be blocked by prednisolone treatment in a sheep model. Methods: The infraspinatus tendon was released in 6 alpine sheep. Directly after the procedure, the sheep were injected daily with intramuscular prednisolone (Prednisolut®) in a dose of 0.5mg/kg body weight. All sheep underwent repair of the retracted musculotendinous unit after 16 weeks and were sacrificed after 22 weeks. Due to ethical reasons the data of 6 sheep from a prior study of our institution were used as the control group. These sheep were treated with the identical study protocol with exception of the prednisolone treatment. Fatty infiltration, muscle volume and myotendinous retraction were measured on MRI preoperatively, after 6 weeks, and before ISP repair (=16 weeks) and at scarification (=22 weeks). Results: The progression of fatty infiltration after tendon repair in the prednisolone group (mean, 53% ±6 at 16 weeks and mean 54%±11 at 22 weeks) was significantly lower (p=0.024) compared to the control group (49% ± 5 at 16 weeks and 61% ±7 after 22 weeks). The muscle volume decreased to a mean of 80% ±5% after 22 weeks in the prednisolone group, and to a mean of 69% ±8 at 22 weeks in the control group (p=0.089). The prednisolone group showed no muscle volume loss after tendon repair (80% ± 7 at 16 weeks and 81% ± 5 at 22 weeks), whereas the control group showed a significantly higher (p=0.034) loss of muscle volume after tendon repair (78% ±8 at 16 weeks and 69% ±8 at 22 weeks). No differences were seen in the distances of retraction of the greater tuberosity bone chip which corresponds for the tendon retraction (7cm ±0.9 prednisolone group, 7cm ± 0.5 control group, p=0.709). Conclusion: Intramuscular prednisolone treatment after tendon release causes less progression of fatty infiltration and less muscle volume loss after tendon repair in sheep. Myotendinous retraction is not influenced by i.m. prednisolone treatment in sheep. |